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C57BL/6J mice exposed to eight flurothyl‐induced generalized clonic seizures exhibit a change in seizure phenotype following a 28‐day incubation period and subsequent flurothyl rechallenge. Mice now develop a complex seizure… Click to show full abstract
C57BL/6J mice exposed to eight flurothyl‐induced generalized clonic seizures exhibit a change in seizure phenotype following a 28‐day incubation period and subsequent flurothyl rechallenge. Mice now develop a complex seizure semiology originating in the forebrain and propagating into the brainstem seizure network (a forebrain→brainstem seizure). In contrast, this phenotype change does not occur in seizure‐sensitive DBA/2J mice. The underlying mechanism was the focus of this study.
Keywords:
eight flurothyl;
brainstem seizure;
flurothyl induced;
exposed eight;
mice exposed;
seizure
Journal Title: Epilepsia Open
Year Published: 2017
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Journal Title: Epilepsia Open
Year Published: 2017
Link to full text (if available)
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recommendations!