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Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis

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Studies have addressed the potential involvement of L‐12/15‐lipoxygenases (LOs), a polyunsaturated fatty acid metabolizing enzyme, in experimental models of acute stroke and chronic neurodegeneration; however, none to our knowledge has… Click to show full abstract

Studies have addressed the potential involvement of L‐12/15‐lipoxygenases (LOs), a polyunsaturated fatty acid metabolizing enzyme, in experimental models of acute stroke and chronic neurodegeneration; however, none to our knowledge has explored its role in epilepsy development. Thus, this study characterizes the cell‐specific expression of L‐12/15 ‐LO in the brain and examines its contribution to epileptogenesis.

Keywords: increased mortality; epileptogenesis; show increased; mice lacking; lipoxygenase show; lacking lipoxygenase

Journal Title: Epilepsia Open
Year Published: 2018

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