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One‐year cost‐effectiveness of callosotomy vs vagus nerve stimulation for drug‐resistant seizures in Lennox‐Gastaut Syndrome: A decision analytic model

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Palliative epilepsy surgery via corpus callosotomy (CC) or vagus nerve stimulation (VNS) is commonly employed for drug‐resistant seizures in Lennox‐Gastaut Syndrome (LGS). VNS is less effective at reducing seizures but… Click to show full abstract

Palliative epilepsy surgery via corpus callosotomy (CC) or vagus nerve stimulation (VNS) is commonly employed for drug‐resistant seizures in Lennox‐Gastaut Syndrome (LGS). VNS is less effective at reducing seizures but has fewer adverse events, CC is more effective for seizure control, particularly atonic seizures, but can be associated with serious adverse events, and yet their relative cost‐effectiveness remains unknown.

Keywords: resistant seizures; seizures lennox; nerve stimulation; vagus nerve; drug resistant; callosotomy vagus

Journal Title: Epilepsia Open
Year Published: 2021

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