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Etiological diagnosis of late‐onset epilepsy: A key priority for Italian epileptologists – Insights from a LICE survey

The incidence of epilepsy rises markedly after age 50. While late‐onset epilepsy (LOE) is often linked to structural brain abnormalities, non‐structural factors, such as infections, autoimmune disorders, and neurodegenerative diseases,… Click to show full abstract

The incidence of epilepsy rises markedly after age 50. While late‐onset epilepsy (LOE) is often linked to structural brain abnormalities, non‐structural factors, such as infections, autoimmune disorders, and neurodegenerative diseases, also contribute. Approximately 20% of LOE cases remain of unknown etiology (LOEU). This study evaluated the diagnostic and therapeutic strategies employed by Italian epileptologists in managing LOE and LOEU, with the ultimate goal of proposing a standardized diagnostic algorithm.

Keywords: onset epilepsy; late onset; etiological diagnosis; epilepsy; italian epileptologists

Journal Title: Epilepsia Open
Year Published: 2025

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