LAUSR

Benzotriazole UV-stabilizers (BZT-UVs) are commonly used as additives to protect from light-induced degradation in a variety of consumer goods. Despite their widespread presence in aquatic ecosystems, information on the effects of these compounds remain largely unknown. The objectives of the present study were to evaluate the chronic effects of two BZT-UVs alone and in a mixture, 2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol (UV-234) and 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV-328), in juvenile rainbow trout (Oncorhynchus mykiss) chronically exposed (28-d) through the diet. Chemical analyses of livers from exposed trout suggested liver accumulation and potential metabolism of the two compounds. Hepatic RNA-sequencing analyses revealed specific effects of each compound on gene transcription profiles; UV-234 affected mainly genes involved in cellular metabolism, while UV-328 induced the transcription of ribosomal proteins and down-regulated genes involved in immune responses. Both compounds regulated iron homeostasis genes in an opposite manner. The mixture of both BZT-UVs did not produce significant evidence of additive or synergistic effects. This article is protected by copyright. All rights reserved.