LAUSR

As an essential regulator of DNA damage, ataxia‐telangiectasia mutated (ATM) gene has been widely studied in oncology. However, the independent effects of ATM missense variants and protein‐truncating variants (PTVs) on neoplasms have not been heavily studied. Whole‐exome sequencing data and the clinical health records of 394,694 UK Biobank European participants were used in this analysis. We mined genetic associations from gene‐level and variant‐level phenome‐wide association studies, and conducted a variant‐level conditional association study to test whether the effects of ATM missense variants on neoplasms were independent of ATM PTV carrier status. The gene‐level PTV collapsing analysis was consistent with established ATM PTV literature showing that the aggregated impact of 286 ATM PTVs significantly (p < 2 × 10−9) associated with 31 malignant neoplasm phenotypes. Of 773 distinct protein‐coding variants in ATM, three individual missense variants significantly (p < 2 × 10−9) associated with nine phenotypes. Remarkably, although the nine phenotypes were tumor‐related, none overlapped the established ATM PTV‐linked malignancies. A subsequent conditional analysis identified that the missense signals were acting independently of the known clinically relevant ATM PTVs.