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Mesenchymal chondrosarcoma of the head and neck with HEY1::NCOA2 fusion: A clinicopathologic and molecular study of 13 cases with emphasis on diagnostic pitfalls

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Mesenchymal chondrosarcoma (MCS) is a rare translocation‐associated sarcoma, driven by a canonical HEY1::NCOA2 fusion. The tumors typically have a biphasic phenotype of primitive small blue round cells intermixed with hyaline… Click to show full abstract

Mesenchymal chondrosarcoma (MCS) is a rare translocation‐associated sarcoma, driven by a canonical HEY1::NCOA2 fusion. The tumors typically have a biphasic phenotype of primitive small blue round cells intermixed with hyaline cartilage. The head and neck (HN) region is a common site for MCS, accounting for 12–45% of all cases reported.

Keywords: head neck; mesenchymal chondrosarcoma; ncoa2 fusion; chondrosarcoma head; hey1 ncoa2

Journal Title: Genes
Year Published: 2022

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