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Evaluation of saliva as a source of accurate whole‐genome and microbiome sequencing data

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This study sets out to establish the suitability of saliva‐based whole‐genome sequencing (WGS) through a comparison against blood‐based WGS. To fully appraise the observed differences, we developed a novel technique… Click to show full abstract

This study sets out to establish the suitability of saliva‐based whole‐genome sequencing (WGS) through a comparison against blood‐based WGS. To fully appraise the observed differences, we developed a novel technique of pseudo‐replication. We also investigated the potential of characterizing individual salivary microbiomes from non‐human DNA fragments found in saliva.

Keywords: whole genome; accurate whole; evaluation saliva; source accurate; saliva source; genome

Journal Title: Genetic Epidemiology
Year Published: 2021

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