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Mendelian randomization (MR) leverages genetic data as an instrumental variable to provide estimates for the causal effect of an exposure X on a health outcome Y that is robust to… Click to show full abstract
Mendelian randomization (MR) leverages genetic data as an instrumental variable to provide estimates for the causal effect of an exposure X on a health outcome Y that is robust to confounding. Unfortunately, horizontal pleiotropy—the direct association of a genetic variant with multiple phenotypes—is highly prevalent and can easily render a genetic variant an invalid instrument.
Keywords:
randomization;
sample;
mendelian randomization;
weak pleiotropy;
pleiotropy robust
Journal Title: Genetic Epidemiology
Year Published: 2023
Link to full text (if available)
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Journal Title: Genetic Epidemiology
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!