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Different apathy clinical profile and neural correlates in behavioral variant frontotemporal dementia and Alzheimer's disease

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Apathy is one of the most common and disabling syndromes of dementia. Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and… Click to show full abstract

Apathy is one of the most common and disabling syndromes of dementia. Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), although evidence is scarce and poorly understood. Our main purposes were to compare the clinical apathy profile from patients with bvFTD and AD and analyze the relationship between apathy and brain metabolism measured using positron emission tomography imaging with 18F fluorodeoxyglucose (FDG‐PET).

Keywords: alzheimer disease; frontotemporal dementia; variant frontotemporal; behavioral variant

Journal Title: International Journal of Geriatric Psychiatry
Year Published: 2018

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