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Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes

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The APOE‐ε4 genotype has been associated with old‐age depression, but this relationship has been rarely investigated in type 2 diabetes (T2D) older adults, who are at significantly increased risk for… Click to show full abstract

The APOE‐ε4 genotype has been associated with old‐age depression, but this relationship has been rarely investigated in type 2 diabetes (T2D) older adults, who are at significantly increased risk for depression, a major contributor to T2D complications. We examined whether trajectories of depression symptoms over time differ by APOE‐ε4 genotype in older adults with T2D.

Keywords: depression; depression symptoms; genotype; type diabetes; trajectories depression; older adults

Journal Title: International Journal of Geriatric Psychiatry
Year Published: 2021

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