LAUSR

cholestasis. HEPATOLOGY 2016;64:535-548. 3) Marrone J, Lehmann GL, Soria LR, Pellegrino JM, Molinas S, Marinelli RA. Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen induced cholestasis. Gene Ther 2014;21:1058-1064. 4) Huebert RC, Splinter PL, Garc ıa F, Marinelli RA, LaRusso NF. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. J Biol Chem 2002;277: 22710-22717. 5) Jessner W, Zsembery A, Graf J. Transcellular water transport in hepatobiliary secretion and role of aquaporinas in liver. Wien Med Wochenschr 2008;158:565-569. 6) Marinelli RA, Tietz P, Caride A, Huang B, LaRusso NF. Water transporting properties of hepatocyte basolateral and canalicular plasma membrane domains. J Biol Chem 2003;278:43157-43162. 7) Larocca MC, Soria LR, Espelt MV, Lehmann GL, Marinelli RA. Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport Am J Physiol 2009;296:G93-G100. 8) Yang B, Song Y, Zhao D, Verkman AS. Phenotype analysis of aquaporin-8 deficient mice. Am J Physiol 2005;288:C1161-C1170. 9) Carreras FI, Gradilone SA, Mazzone A, Garc ıa F, Ochoa JE, Tietz P, et al. Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis. HEPATOLOGY 2003; 37:1026-1033. 10) Carreras FI, Lehmann GL, Ferri D, Tioni MF, Calamita G, Marinelli RA. Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogeninduced cholestasis. Am J Physiol 2007;292:G905-G912. 11) Lehmann GL, Carreras FI, Soria LR, Gradilone SA, Marinelli RA. LPS induces the TNFa-mediated down-regulation of rat liver aquaporin-8: role in sepsis-associated cholestasis. Am J Physiol 2008;294:G567-G575. 12) Lehmann GL, Marinelli RA. Peritoneal sepsis down-regulates liver expression of aquaporin-8, a water channel involved in bile secretion. Liver Int 2009;29:317-318.