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Immune-mediated drug-induced liver injury (IM-DILI) can be triggered by biologic agents, in addition to traditional drugs, including statins, minocycline, and nitrofurantoin. IM-DILI may be indistinguishable at presentation from autoimmune hepatitis… Click to show full abstract
Immune-mediated drug-induced liver injury (IM-DILI) can be triggered by biologic agents, in addition to traditional drugs, including statins, minocycline, and nitrofurantoin. IM-DILI may be indistinguishable at presentation from autoimmune hepatitis (AIH) and cessation of the causative drug is often not followed by improvement (1). Olaparib is the first-in-class oral poly(ADP-ribose) polymerase inhibitor (an enzyme involved in DNA transcription and repair) and is approved as maintenance treatment in platinum-sensitive, relapsed ovarian cancer with BRCA1/2 mutation. This article is protected by copyright. All rights reserved.
Journal Title: Hepatology
Year Published: 2018
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