Photo by viooview from unsplash
Overactivation of the innate immune response amplifies hepatic injury and promotes the progression to fibrosis and cirrhosis in many liver diseases. Hepatic and systemic inflammation are triggered in part by… Click to show full abstract
Overactivation of the innate immune response amplifies hepatic injury and promotes the progression to fibrosis and cirrhosis in many liver diseases. Hepatic and systemic inflammation are triggered in part by factors released from dying hepatocytes, but recent evidence demonstrates that increased inflammation occurs in end-stage cirrhotic liver disease which typically has low levels of hepatocyte injury.(1) Clinical decompensation in patients with cirrhosis is associated with increased inflammation which is even greater in patients with acute-on-chronic liver failure (ACLF).(2) This article is protected by copyright. All rights reserved.
Journal Title: Hepatology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!