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Antiprogrammed Cell Death‐1 Immunotherapy‐Related Secondary Sclerosing Cholangitis

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Secondary sclerosing cholangitis (SSC) is a rare disease that is associated with various etiologies. Recent development of immune checkpoint inhibitors demonstrates efficacy in the treatment of various malignancies; however, these… Click to show full abstract

Secondary sclerosing cholangitis (SSC) is a rare disease that is associated with various etiologies. Recent development of immune checkpoint inhibitors demonstrates efficacy in the treatment of various malignancies; however, these inhibitors can also cause immune-related adverse events, including inflammatory manifestations. We are the first group of researchers to report on pembrolizumab-induced SSC through imaging and histological analyses. This article is protected by copyright. All rights reserved.

Keywords: antiprogrammed cell; cell death; secondary sclerosing; sclerosing cholangitis; death immunotherapy

Journal Title: Hepatology
Year Published: 2019

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