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Endogenous interferon signaling is the body's first line of defense against viruses, providing the rationale for use of IFN as the backbone of treatment for viral hepatitis for over two… Click to show full abstract
Endogenous interferon signaling is the body's first line of defense against viruses, providing the rationale for use of IFN as the backbone of treatment for viral hepatitis for over two decades. Hepatitis C viral RNA is recognized by innate pattern recognition receptors (PRRs) residing within the cytoplasmic or endosomal compartments. These PRRs include the cytoplasmic sensor retinoic acid inducible gene-I (RIG-I), Nod-like receptors, and endosomal toll-like receptor-3 (TLR3). This article is protected by copyright. All rights reserved.
Journal Title: Hepatology
Year Published: 2018
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