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We read the paper by Nardelli et al with great interest.1 The study tried to establish the correlation between using of proton pump inhibitors (PPIs) and the occurrence of minimal/overt hepatic… Click to show full abstract
We read the paper by Nardelli et al with great interest.1 The study tried to establish the correlation between using of proton pump inhibitors (PPIs) and the occurrence of minimal/overt hepatic encephalopathy (HE) among cirrhotics. In accordance with our previous retrospective population study,2 Nardelli et al. confirmed that PPI users in cirrhotics were at higher risk to develop overt HE in their prospective cohort. They further provided evidence to support PPI use was also an independent factor in determining minimal HE occurrence. In addition, PPI users were found to have significantly lower survival than PPI non-users (41% vs 81%; p<0.001) and PPIs were identified as one of the independent factors in association with mortality. This article is protected by copyright. All rights reserved.
Journal Title: Hepatology
Year Published: 2019
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