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Paneth Cell Dysfunction Mediates Alcohol‐related Steatohepatitis Through Promoting Bacterial Translocation in Mice: Role of Zinc Deficiency

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Microbial dysbiosis is associated with alcohol‐related hepatitis (AH), with the mechanisms yet to be elucidated. The present study aimed to determine the effects of alcohol and zinc deficiency on Paneth… Click to show full abstract

Microbial dysbiosis is associated with alcohol‐related hepatitis (AH), with the mechanisms yet to be elucidated. The present study aimed to determine the effects of alcohol and zinc deficiency on Paneth cell (PC) antimicrobial peptides, α‐defensins, and to define the link between PC dysfunction and AH.

Keywords: zinc deficiency; alcohol related; paneth cell

Journal Title: Hepatology
Year Published: 2019

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