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Small but Mighty: Platelets in NASH and Other Chronic Liver Diseases

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Recent studies have identified several pleiotropic effects of platelets on liver homeostasis and disease distinct from their long-recognized roles in hemostasis and coagulation. Concerns for bleeding have traditionally limited the… Click to show full abstract

Recent studies have identified several pleiotropic effects of platelets on liver homeostasis and disease distinct from their long-recognized roles in hemostasis and coagulation. Concerns for bleeding have traditionally limited the use of anti-platelet agents in advanced liver disease. However, recent evidence increasingly suggests that pro-thrombotic tendencies may exceed the bleeding diathesis traditionally associated with advanced liver disease. This implies that anti-platelet therapy (APT) may in fact be safely used in certain patients with chronic liver disease.

Keywords: disease; small mighty; mighty platelets; chronic liver; liver disease

Journal Title: Hepatology
Year Published: 2020

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