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PNPLA3 Genotype and Risk of Liver and All‐Cause Mortality

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Mirroring the obesity pandemic, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease affecting populations worldwide. Approximately 30% of the adult United States (US) population is estimated… Click to show full abstract

Mirroring the obesity pandemic, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease affecting populations worldwide. Approximately 30% of the adult United States (US) population is estimated to be afflicted with NAFLD. NAFLD is a spectrum of liver disease ranging from nonalcoholic fatty liver (NAFL), the non-progressive sub-type, to nonalcoholic steatohepatitis (NASH), the progressive sub-type, which can lead to progressive liver disease leading to cirrhosis and hepatocellular carcinoma(1).

Keywords: pnpla3 genotype; risk liver; liver; genotype risk; liver disease

Journal Title: Hepatology
Year Published: 2020

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