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Exercise‐Induced Hyperammonemia Does Not Precipitate Overt Hepatic Encephalopathy

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Moderate-to-vigorous exercise increases blood ammonia concentrations, potentially contributing to the development of hepatic encephalopathy (HE). Patients with end-stage liver disease (ESLD) often suffer from frailty or physical deconditioning as a… Click to show full abstract

Moderate-to-vigorous exercise increases blood ammonia concentrations, potentially contributing to the development of hepatic encephalopathy (HE). Patients with end-stage liver disease (ESLD) often suffer from frailty or physical deconditioning as a result of sarcopenia, fluid overload/ascites, obesity and concomitant diseases. Exercise is therefore recommended for ESLD patients to reverse or halt progression of frailty/sarcopenia, as these conditions contribute to increased mortality.

Keywords: exercise induced; induced hyperammonemia; hepatic encephalopathy; hyperammonemia precipitate; exercise

Journal Title: Hepatology
Year Published: 2020

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