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Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes

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Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X… Click to show full abstract

Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X receptors (LXRs), which belong to the superfamily of nuclear hormone receptors, are important physiological regulators of lipid and cholesterol metabolism. However, the association between the LXR pathway and HBV infection remains largely unclear.

Keywords: liver receptor; receptor pathway; hbv infection; pathway inhibits; replication; activation liver

Journal Title: Hepatology
Year Published: 2020

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