LAUSR

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease globally. It can progress to the more severe nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). The liver is a major site for lipid metabolism, a process that is strictly regulated by a series of steps, including fatty acid uptake; de novo lipogenesis (DNL); triglyceride (TG) synthesis, esterification, and storage; and fatty acid β-oxidation and very low-density lipoprotein (VLDL) secretion. An imbalance between the lipid input (intake and biosynthesis of TGs) and output (export and catabolism of TGs) can result in NAFLD and further progress to NASH.