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Noninvasive Tests to Phenotype Nonalcoholic Fatty Liver Disease: Sequence and Consequences of Arranging the Tools in the Tool Box

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Characterizing the severity of nonalcoholic fatty liver disease (NAFLD) is essential for risk stratification and optimizing the management plan. For long, a liver biopsy was the sole option to diagnose… Click to show full abstract

Characterizing the severity of nonalcoholic fatty liver disease (NAFLD) is essential for risk stratification and optimizing the management plan. For long, a liver biopsy was the sole option to diagnose NAFLD patients with nonalcoholic steatohepatitis (NASH) who are at risk of progression and those with advanced fibrosis who are at a higher risk of incident liver-related morbidity and mortality.1 However, the high prevalence of NAFLD and the invasive nature of liver biopsy has placed a barrier for the diagnosis of NASH.1 This bottleneck thankfully fueled the need to develop several non-invasive approaches to identify patients with NAFLD who are at increased risk of developing liver-related morbidity and mortality without the need for receiving a liver biopsy assessment.

Keywords: risk; fatty liver; liver biopsy; nonalcoholic fatty; liver disease

Journal Title: Hepatology
Year Published: 2021

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