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Studies of the identity and pathophysiology of fibrogenic HSCs have been hampered by a lack of genetic tools that permit specific and inducible fate‐mapping of these cells in vivo. Here,… Click to show full abstract
Studies of the identity and pathophysiology of fibrogenic HSCs have been hampered by a lack of genetic tools that permit specific and inducible fate‐mapping of these cells in vivo. Here, by single‐cell RNA sequencing of nonparenchymal cells from mouse liver, we identified transcription factor 21 (Tcf21) as a unique marker that restricted its expression to quiescent HSCs.
Keywords:
perivenous stellate;
source myofibroblasts;
myofibroblasts cancer;
cells main;
main source;
stellate cells
Journal Title: Hepatology
Year Published: 2021
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Journal Title: Hepatology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!