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New Glance at the Role of TM6SF2 in Lipid Metabolism and Liver Cancer

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Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver diseases. NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH), cirrhosis and… Click to show full abstract

Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver diseases. NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC), which confer increased morbidity and mortality. However, many individuals with NAFLD do not progress to these more severe conditions. Such variations in the susceptibility of NAFLD progression suggest that it is likely affected by multiple factors, in particular, genetic factors.

Keywords: metabolism liver; tm6sf2 lipid; new glance; role tm6sf2; lipid metabolism; glance role

Journal Title: Hepatology
Year Published: 2021

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