LAUSR

Chronic HBV infection (CHI) is associated with a diverse natural history that includes immune‐tolerant (IT), HBeAg‐positive chronic hepatitis B (CHB) (EP‐CHB), inactive carrier, and HBeAg‐negative CHB (EN‐CHB) phases. A hallmark of CHI is impairment of HBV‐specific T‐cell response. Recently, myeloid‐derived suppressor cells (MDSCs) have emerged as key regulator of T cells, and their properties are sculpted by their microenvironment. Here, we investigated the distinctive features of MDSCs during CHI, identified factors responsible for their functional discrepancies, and studied their impact on HBV‐specific T‐cell response and homing. Influence of antiviral therapy on MDSC profile and T‐cell response was also assessed.