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We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto’s bifunctional organocatalyst. This approach allows for the synthesis of various novel β2,2-amino… Click to show full abstract
We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto’s bifunctional organocatalyst. This approach allows for the synthesis of various novel β2,2-amino acid-phthalide conjugates with good enantio- and diastereoselectivities in reasonable yields and the further ring-opening of these compounds to acyclic carboxylic acid derivatives was demonstrated too.
Keywords:
acid containing;
masked amino;
syntheses masked;
acid;
stereoselective syntheses;
amino acid
Journal Title: Helvetica chimica acta
Year Published: 2022
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Journal Title: Helvetica chimica acta
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!