LAUSR

del17p – 5.6% (9/159); 1p32/1q21 amp/del – 12% (19/159); hypodiploidy – 3.1% (5/159); hyperdiploidy – 1.25% (2/159); del5q – 0,6% (1/159); other – not found. Combination two aberrations was discovered in 11.9% (19/159) patients, complex abnormalities (>3 aberrations) – in 4.4% (7/159) patients. The median OS in “two aberration” and “complex abnormalities” groups were lower than in standard-risk mSMART 3.0 (normal, t(11;14), hypodiploidy, hyperdiploidy and other): 49 months, 37 months and not reached, respectively (p=.02). The median PFS for these groups was 12 months, 11 months and 30 months, respectively (p=0.004). We modified high-risk mSMART 3.0 by adding “two aberration” and “complex abnormalities” groups on based the OS and PFS results. The median OS in standard-risk mSMART 3.0 was not reached, in high-risk mSMART 3.0 – 50 months; 5-years OS was 65% and 38%, respectively (p=0.01). The median PFS was 58 and 29 months, respectively (p=.02). Conclusion: Combination two aberrations and complex abnormalities are unfavorable prognostic markers. The median OS and PFS was higher in standard-risk than high-risk patients mSMART 3.0. It can be useful for update risk stratification in future.