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CASE MATCH CONTROL ANALYSIS OF PROPEL REVEALS A SURVIVAL ADVANTAGE FOR PATIENTS WITH RELAPSED PTCL RECEIVING PRALATREXATE: A NOVEL APPROACH TO BENCHMARK DRUGS IN RARE DISEASES

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and two had treatment tolerance requiring a change in therapy. In this group (n = 24), the median OS after BV failure was only 3 months, and 2‐year OS was… Click to show full abstract

and two had treatment tolerance requiring a change in therapy. In this group (n = 24), the median OS after BV failure was only 3 months, and 2‐year OS was 30%. Of 6 long‐term (>1 year) survivors, five underwent subsequent SCT (allo n = 3, auto n = 2). One had good response to investigational clinical trial treatment, and one had localized indolent disease. Conclusions: Refractory disease to last therapy and higher sIPI at start of BV were associated with inferior outcomes in ALCL following BV. Further, patients with disease progression after use of BV have a dismal outcome.

Keywords: reveals survival; analysis propel; case match; propel reveals; control analysis; match control

Journal Title: Hematological Oncology
Year Published: 2017

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