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IBRUTINIB INCREASES THE SYSTEMIC EXPOSURE OF RITUXIMAB: PHARMACOKINETIC RESULTS FROM THE HELIOS TRIAL

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decreased lymphoma‐specific mortality, adjusted HR 0.09 (0.01, 0.64). Further dose‐response analyses are planned. Conclusions: In this very large population‐based unselected lymphoma population, statins were not associated with worse outcomes and… Click to show full abstract

decreased lymphoma‐specific mortality, adjusted HR 0.09 (0.01, 0.64). Further dose‐response analyses are planned. Conclusions: In this very large population‐based unselected lymphoma population, statins were not associated with worse outcomes and thus appear safe to use during lymphoma treatment. Interestingly, Burkitt patients using statins had a statistically significant decreased lymphoma‐specific mortality.

Keywords: pharmacokinetic results; exposure rituximab; ibrutinib increases; increases systemic; systemic exposure; rituximab pharmacokinetic

Journal Title: Hematological Oncology
Year Published: 2017

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