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Long‐term SARS‐CoV‐2‐specific and cross‐reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology

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Cellular immune memory responses post coronavirus disease 2019 (COVID‐19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous… Click to show full abstract

Cellular immune memory responses post coronavirus disease 2019 (COVID‐19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The work herein presents a large‐scale long‐term follow‐up study investigating the correlation between symptomology and cellular immune responses four to five months post seroconversion based on a unique severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐specific peptide pool that contains no overlapping peptides with endemic human coronaviruses.

Keywords: sars cov; symptomatology; cellular immune; long term; cov specific; immune responses

Journal Title: Immunity
Year Published: 2022

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