LAUSR

Surgery is the mainstay curative treatment in most cancer. We aimed to test the new hypothesis that cancer surgery performed during holiday periods is associated with worse long‐term prognosis than for non‐holiday periods. This nationwide Swedish population‐based cohort study included 228,927 patients during 1997–2014 who underwent elective resectional surgery for a cancer where the annual number of resections was over 100. The 16 eligible cancer sites were grouped into 10 cancer groups. The exposure, holiday periods, was classified as wide (14‐weeks) or narrow (7‐weeks). Surgery conducted inside versus outside holiday periods was compared regarding overall disease‐specific (main outcome) and overall all‐cause (secondary outcome) mortality. Cox regression provided hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, sex, comorbidity, hospital volume, calendar period and tumor stage. Surgery conducted during wide and narrow holiday periods were associated with increased HRs of disease‐specific mortality for cancer of the breast (HR 1.08, 95% CI 1.03–1.13 and HR 1.06, 95% CI 1.01–1.12) and possibly of cancer of the liver‐pancreas‐bile ducts (HR 1.09, 95% CI 0.99–1.20 and HR 1.12, 95% CI 0.99–1.26). Sub‐groups with cancer of the colon‐rectum, head‐and‐neck, prostate, kidney‐urine bladder and thyroid also experienced statistically significantly worse prognosis following surgery conducted during holiday periods. No influence of surgery during holiday was detected for cancer of the esophagus‐stomach, lung or ovary‐uterus. All‐cause HRs were similar to the disease‐specific HRs. The prognosis following cancer surgery might not be fully maintained during holiday periods for all cancer sites.