Photo by bermixstudio from unsplash
β‐lactams are the most widely used antibiotics and are effective against a spectrum of pathogenic bacteria. Here, we focus on the state‐of‐the‐art understanding of the molecular underpinnings that determine the… Click to show full abstract
β‐lactams are the most widely used antibiotics and are effective against a spectrum of pathogenic bacteria. Here, we focus on the state‐of‐the‐art understanding of the molecular underpinnings that determine the overall efficacy of β‐lactams against TB and include historical perspectives of this antibiotic class against this ancient disease. We summarize literature that describes why earlier generations of β‐lactams are ineffective and the potential promise of newer β‐lactams that exhibit improved efficacy against TB. Emerging evidence warrants renewed consideration of newer β‐lactams in regimens for treatment of drug‐resistant TB. © 2018 IUBMB Life, 70(9):881–888, 2018
Journal Title: IUBMB Life
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!