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Most flavors used in e‐liquids are generally recognized as safe for oral consumption, but their potential effects when inhaled are not well characterized. In vivo inhalation studies of flavor ingredients… Click to show full abstract
Most flavors used in e‐liquids are generally recognized as safe for oral consumption, but their potential effects when inhaled are not well characterized. In vivo inhalation studies of flavor ingredients in e‐liquids are scarce. A structure‐based grouping approach was used to select 38 flavor group representatives (FGR) on the basis of known and in silico‐predicted toxicological data. These FGRs were combined to create prototype e‐liquid formulations and tested against cigarette smoke (CS) in a 5‐week inhalation study.
Journal Title: Journal of Applied Toxicology
Year Published: 2022
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