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The protective effects of azilsartan against oscillatory shear stress‐induced endothelial dysfunction and inflammation are mediated by KLF6

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Atherosclerosis is a common cardiovascular disease with high morbidity and mortality. It is reported to be related to oscillatory shear stress (OSS)‐induced endothelial dysfunction and excessive production of inflammatory factors.… Click to show full abstract

Atherosclerosis is a common cardiovascular disease with high morbidity and mortality. It is reported to be related to oscillatory shear stress (OSS)‐induced endothelial dysfunction and excessive production of inflammatory factors. Azilsartan, a specific antagonist of the angiotensin II receptor, has been approved for the management of hypertensive subjects with diabetes mellitus type II (DMII). The present study will investigate the effects of azilsartan against OSS‐induced endothelial dysfunction and inflammation, as well as the underlying mechanism.

Keywords: induced endothelial; shear stress; effects azilsartan; oscillatory shear; endothelial dysfunction

Journal Title: Journal of Biochemical and Molecular Toxicology
Year Published: 2021

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