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Optimizing management of replacement fluids for therapeutic plasma exchange: Use of an automated mathematical model to predict post‐procedure fibrinogen and antithrombin levels in high‐risk patients

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Therapeutic plasma exchange (TPE) utilizes an extracorporeal circuit to remove pathologic proteins causing serious illness. When processing a patient's entire blood volume through an extracorporeal circuit, proteins responsible for maintaining… Click to show full abstract

Therapeutic plasma exchange (TPE) utilizes an extracorporeal circuit to remove pathologic proteins causing serious illness. When processing a patient's entire blood volume through an extracorporeal circuit, proteins responsible for maintaining hemostatic system homeostasis can reach critically low levels if replacement fluid types and volumes are not carefully titrated, which may increase complications.

Keywords: optimizing management; management replacement; plasma exchange; therapeutic plasma

Journal Title: Journal of Clinical Apheresis
Year Published: 2019

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