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Dachengqi decoction alleviates acute lung injury and inhibits inflammatory cytokines production through TLR4/NF‐κB signaling pathway in vivo and in vitro

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Sepsis that arises from uncontrolled pulmonary inflammation could induce acute lung injury (ALI), leading to the high death rate. Dachengqi decoction (DCQD) is a common traditional Chinese herbal medicine with… Click to show full abstract

Sepsis that arises from uncontrolled pulmonary inflammation could induce acute lung injury (ALI), leading to the high death rate. Dachengqi decoction (DCQD) is a common traditional Chinese herbal medicine with strong anti‐inflammatory effects. The current study aimed to explore the effect of DCQD on the inflammatory cytokines production, the aquaporin‐1 (AQP‐1) and AQP‐5 protein expression in lipopolysaccharide (LPS)‐induced ALI models, and the potential mechanisms underlying its effects.

Keywords: dachengqi decoction; cytokines production; acute lung; inflammatory cytokines; lung injury

Journal Title: Journal of Cellular Biochemistry
Year Published: 2019

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