LAUSR

Acute lymphoblastic leukemia (ALL) is characterized by excessive accumulation of lymphoblast and progenitors. Leukemia is the most common cancer in children and ALL is the most common subtype. Many studies have shown that the YKL‐40 gene is one of the most widely expressed genes in tumors, including leukemia, but not in healthy blood cells. Clinical studies have shown that serum YKL‐40 levels have a positive correlation with tumor expansion, in addition to being a prognostic agent independent of a short relapse‐free interval, as well as a brief overall survival in patients with various cancers. The previous study shows that YKL‐40 is closely related to the degree of pathology or degree of human leukemia pathology and plays an important role in cell proliferation. Hence, the YKL‐40 can be an attractive target in designing anticancer therapies.