LAUSR

Aggregation of amyloid‐β (Aβ) peptides represents a crucial step in the pathogenesis of Alzheimer disease (AD). Compelling evidence from preclinical studies has established that statins may reduce amyloidogenesis and Aβ‐mediated neurodegeneration, supporting a potential role of statin treatment in the prevention of AD. Different statins have been shown to interfere indirectly with Aβ production and clearance through either cholesterol‐dependent or cholesterol‐independent mechanisms. However, whether there may be a direct interaction between statins and Aβ metabolism is still unclear.