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Gene therapy by lentivirus‐mediated RNA interference targeting extracellular‐regulated kinase alleviates neuropathic pain in vivo

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Neuropathic pain is an abnormal pain, which is related to the activation of extracellular‐regulated kinase (ERK) signaling. This study was to investigate the effects of ERK knockdown via lentivirus‐mediated RNA… Click to show full abstract

Neuropathic pain is an abnormal pain, which is related to the activation of extracellular‐regulated kinase (ERK) signaling. This study was to investigate the effects of ERK knockdown via lentivirus‐mediated RNA interference on allodynia in rats with chronic compression of the dorsal root ganglia (DRG) and to uncover the potential mechanisms.

Keywords: lentivirus mediated; extracellular regulated; mediated rna; regulated kinase; neuropathic pain; pain

Journal Title: Journal of Cellular Biochemistry
Year Published: 2018

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