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Cardiovascular risk increases in women after menopause. Unfavorable lipid‐lipoprotein changes due to a lack of estrogens may have an important role in this context. Estrogen actions are mainly mediated by… Click to show full abstract
Cardiovascular risk increases in women after menopause. Unfavorable lipid‐lipoprotein changes due to a lack of estrogens may have an important role in this context. Estrogen actions are mainly mediated by their binding to two estrogen receptors (ERs) whose signaling may be conditioned by different factors. Calcium, vitamin D, and genistein, among others, cause a beneficial effect on serum lipid profile by its modulation. Some genetic factors can also determine this signal. We determined the possible additive effect of genistein on calcium and vitamin D supplementation regarding serum lipid profile changes and whether ER polymorphisms may mediate in this effect.
Journal Title: Journal of Cellular Biochemistry
Year Published: 2019
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