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Inhibition of mitochondrial activity ameliorates atherosclerosis in ApoE−/− mice via suppressing vascular smooth cell activation and macrophage foam cell formation

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Atherosclerosis involves disorders in lipoprotein metabolism and inflammation. Mitochondrial dysfunction plays a critical role in promoting cell apoptosis, inflammation, and oxidative stress involved in the progress of atherosclerosis. Whereas the… Click to show full abstract

Atherosclerosis involves disorders in lipoprotein metabolism and inflammation. Mitochondrial dysfunction plays a critical role in promoting cell apoptosis, inflammation, and oxidative stress involved in the progress of atherosclerosis. Whereas the direct effect of mitochondrial activity modulation on atherogenesis remains unclear. This study evaluated the effect of a mitochondrial complex inhibitor on atherosclerosis in ApoE‐deficient mice as well as the potential mechanisms.

Keywords: atherosclerosis apoe; mice; mitochondrial activity; cell; atherosclerosis

Journal Title: Journal of Cellular Biochemistry
Year Published: 2019

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