Photo by vlisidis from unsplash
A series of novel N-alkylcarbazol–propargylamine hybrids were designed and synthesized by CuIBr-catalyzed A3-coupling of N-octylcarbazol-3-carbaldehyde, amines, and alkynes. The tri-substituted propargyl amines decorated with carbazole moiety were obtained under solvent-free… Click to show full abstract
A series of novel N-alkylcarbazol–propargylamine hybrids were designed and synthesized by CuIBr-catalyzed A3-coupling of N-octylcarbazol-3-carbaldehyde, amines, and alkynes. The tri-substituted propargyl amines decorated with carbazole moiety were obtained under solvent-free conditions in good to moderate yields. Furthermore, the scope of the method was studied, which was found to be applicable to primary aliphatic and aromatic amines. Also, a large variety of substituents both on alkynes and anilines are well tolerated.
Journal Title: Journal of The Chinese Chemical Society
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!