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Proteolytic cleavage through proteases affects peptide hormone levels, which is of particular significance when the time interval between sampling and analysis is prolonged. We evaluated the stability of parathyroid hormone,… Click to show full abstract
Proteolytic cleavage through proteases affects peptide hormone levels, which is of particular significance when the time interval between sampling and analysis is prolonged. We evaluated the stability of parathyroid hormone, insulin, and prolactin molecules (i) with different protease inhibitors such as K2EDTA, aprotinin, and protease inhibitor cocktail (PIC), (ii) with different lag times (6‐72 hours), and (iii) under different storage temperatures (4°C vs room temperature [RT]) until analysis.
Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2017
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