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The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children

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Wilms tumor (WT) is the most common urologic cancer in children. However, genetic bases underlying WT remain largely unknown. Previous studies indicated that Lin28 homolog B (LIN28B) level is significantly… Click to show full abstract

Wilms tumor (WT) is the most common urologic cancer in children. However, genetic bases underlying WT remain largely unknown. Previous studies indicated that Lin28 homolog B (LIN28B) level is significantly elevated in some WTs. Enforced expression of Lin28b during kidney development could induce WT. Genetic variations in the LIN28B gene may be related to WT susceptibility.

Keywords: wilms tumor; lin28b gene; susceptibility

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2018

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