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High accuracy of proximity extension assay technology for the quantification of plasma brain natriuretic peptide

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Novel multiplex assays allow the simultaneous identification of a large number of plasma proteins. While these new technologies have been shown to be highly sensitive and accurate for the identification… Click to show full abstract

Novel multiplex assays allow the simultaneous identification of a large number of plasma proteins. While these new technologies have been shown to be highly sensitive and accurate for the identification of plasma proteins, the use of this technology to quantify those proteins has not been properly investigated. In this pilot study, we tested the accuracy of the proximity extension assay (PEA) for the quantification of the cardiac biomarker brain natriuretic peptide (BNP) compared to a standard clinically approved method.

Keywords: brain natriuretic; plasma; proximity extension; extension assay; accuracy proximity; natriuretic peptide

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2018

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