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Association analysis of interleukin‐18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women

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Interleukin‐18‐137G/C, ‐607G/T polymorphisms play multiple roles in various cancers. However, studies focused on its involvement in breast cancer remain controversial, and no study has taken the interaction between interleukin‐18 (IL‐18)… Click to show full abstract

Interleukin‐18‐137G/C, ‐607G/T polymorphisms play multiple roles in various cancers. However, studies focused on its involvement in breast cancer remain controversial, and no study has taken the interaction between interleukin‐18 (IL‐18) gene polymorphism and body mass index (BMI), menopause into consideration. The study investigated the association between IL‐18‐137, ‐607 polymorphisms and risk of breast cancer and a possible interaction between the 2 single nucleotide polymorphisms (SNPs) and BMI, menopause in Chinese Han woman.

Keywords: chinese han; interleukin gene; breast; breast cancer

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2018

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