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Importance of sample volume to the measurement and interpretation of plasma osmolality

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Small sample volumes may artificially elevate plasma osmolality (Posm) measured by freezing point depression. The purpose of this study was to compare two widely different sample volumes of measured Posm… Click to show full abstract

Small sample volumes may artificially elevate plasma osmolality (Posm) measured by freezing point depression. The purpose of this study was to compare two widely different sample volumes of measured Posm (mmol/kg) to each other, and to calculated osmolarity (mmol/L), across a physiological Posm range (~50 mmol/kg).

Keywords: plasma osmolality; plasma; sample volume; importance sample

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2019

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