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Association of peripheral blood neutrophil gelatinase‐associated lipocalin levels with bone marrow neutrophil gelatinase‐associated lipocalin levels and neutrophil count in hematologic malignancy

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Although neutrophil gelatinase‐associated lipocalin (NGAL) is a biomarker for acute kidney injury, recently, high NGAL levels have been reported in hematologic malignancies. Given the mechanism underlying NGAL synthesis and secretion… Click to show full abstract

Although neutrophil gelatinase‐associated lipocalin (NGAL) is a biomarker for acute kidney injury, recently, high NGAL levels have been reported in hematologic malignancies. Given the mechanism underlying NGAL synthesis and secretion in neutrophilic series, it is speculated that NGAL levels are higher in bone marrow (BM) than in peripheral blood (PB). Additionally, PB NGAL levels are thought to be associated with neutrophilic parameters. We aimed to test both hypotheses in hematologic malignancies.

Keywords: gelatinase associated; lipocalin levels; neutrophil gelatinase; associated lipocalin

Journal Title: Journal of Clinical Laboratory Analysis
Year Published: 2019

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